Inflammatory fatty liver disease (NASH, non alcoholic steatohepatitis ) and the resulting liver cancer are driven by autoaggressive T cells. Scientists from the German Cancer Research Center (DKFZ) now show what ist behind this destructive behavior. In both mice and humans with NASH, they found increased numbers of activated B cells in the gastrointestinal tract.

Along with sugar reallocation, a basic molecular mechanism within plants controls the formation of new lateral roots. An international team of plant biologists has demonstrated that it is based on the activity of a certain factor, the target of rapamycin (TOR) protein.

Volkswagen Foundation to fund international research project with around 1.5 million euros. Interdisciplinary team led by the Institute for Global Health at Heidelberg University Hospital to research the transmission of pathogens from animals to humans in Thailand and Laos. Long-term goal is to develop sustainable preventive measures against future pandemics.

Centromeres, the DNA sections often found at the center of the chromosomes, display enormous interspecies diversity, despite having the same vital role during cell division across almost the entire tree of life. An international team of researchers has discovered that the variation in centromere DNA regions can be strikingly large even within a single species. The findings, now published in the journal Nature, shed light on the molecular…

3D-Thermocell project - 17/05/2023

Paper instead of plastic: sustainable packaging with a good conscience

Replacing plastic – for example in packaging – is not that easy but nevertheless urgently needed. In the 3D-Thermocell project, researchers at DHBW Karlsruhe are currently developing new plastic substitute products made of thermoformable paper as a renewable resource, which should be cheap and light and easy to dispose of along with waste paper. The characterisation and application of demonstration models will start soon.

This year's Venice Architecture Biennale sees itself as a "Laboratory of the Future". Bio-composites are not just dreams of the future in architecture. The German Institutes of Textile and Fiber Research (DITF) have developed a sustainable material for support profiles and connecting nodes, which will be on display at Palazzo Mora during the Biennale from May 20 to November 26.

Chronic myeloid leukemia (CML) is a type of blood cancer that arises from malignant changes in blood-forming cells of the bone marrow. It mainly occurs in older individuals and represents about 20 percent of all adult leukemia cases. A research team from the Institute of Molecular Medicine and Cell Research at the University of Freiburg has now demonstrated for the first time that mast cells play a crucial role in the development of CML.

The recently established ITCC-P4 gGmbH provides academic institutions and pharmaceutical companies with a comprehensive repertoire of modern laboratory models of pediatric tumors. The aim is to systematically test new treatment options for children and adolescents with cancer and to contribute data to regulatory approval processes in order to make the development of new cancer therapies for children and adolescents more attractive.

Optogenetic cell analysis - 15/05/2023

opto biolabs: how frustration and inventiveness led to the establishment of a company

When she found she had no suitable illumination devices for her doctoral thesis, Dr. Kathrin Brenker simply created her own customised adapters and founded a company called opto biolabs. Now, Brenker and company co-founder Luis Köbele sell two different types of devices. The main goal is to equip laboratories with illumination technologies that allow optogenetics methods to be used to accelerate development of optogenetic therapeutics.

Proteins have characteristic amino acid sequences, the analysis of which is fundamental for research and medicine. These can be decoded; however, so-called protein sequencing is expensive and time-consuming. A large-scale research project led by Prof. Dr. Jan Behrends from the Institute of Physiology at the University of Freiburg now aims to establish a new technology for protein sequencing using nanopores, which will be rapid and cost-effective.

Researchers at the University of Konstanz publish image analysis software that automatically detects and classifies defects of animal development. Thanks to artificial intelligence, "EmbryoNet" outperforms human experts in terms of speed, accuracy and sensitivity.

Initial Phase 1 part started with multivalent modified mRNA influenza vaccine candidates. Candidates developed in collaboration with GSK within broad infectious disease vaccine program encode for antigens covering four WHO-recommended flu strains.

Diatoms as a biorefinery - 05/05/2023

Microalgae: sustainable chemical production in a mini factory

Renewable raw materials that can be used as alternatives to fossil resources already exist. However, to turn them into everyday products, plant oils and other renewable raw materials not only have to be extracted, but often have to undergo complex chemical processing. Researchers at the University of Konstanz have now converted microalgae cells into tiny refineries to produce and upgrade raw materials, creating a supply of sustainable chemicals.

Triple-negative breast cancer (TNBC) is the most aggressive and deadly form of breast cancer with limited treatment options. Tumor growth and relapse of TNBC are driven by breast cancer stem cells, and improved therapies that can eliminate those hardy cells are urgently needed. Researchers from the University of Frieburg discovered that coordinated differentiation and changes in the metabolism of breast cancer stem cells make them invisible for…

At the Fraunhofer Center for Chemical-Biotechnological Processes CBP in Leuna, Germany, representatives from politics, research and industry opened a novel pilot plant for the mild processing of rapeseed to increase the added-value potential of rape as a raw material.

Sustainability is a major challenge in the food and packaging industry. Plastic packaging is being replaced by organic-based and biodegradable materials, but it must still fulfill high functional requirements. A team of researchers at the University of Hohenheim has developed a new coating system that is both water-impermeable, heat-resistant, and mechanically durable as well as being suitable for consumption, and biodegradable at the same time.

Milana will strengthen the research of the Cluster of Excellence Living, Adaptive and Energy-autonomous Materials (livMatS) in the field and work closely with scientists from the Freiburg Center for Interactive Materials and Bioinspired Technologies (FIT) and the Freiburg Materials Research Center (FMF).

Ready-made meals are ideal for quickly satisfying hunger. However, the quick snacks produce a lot of environmentally harmful plastic waste. To tackle this problem, the student team EDGGY from the University of Hohenheim in Stuttgart rolled up its sleeves and developed edible packaging made from eggshells and other plant-based raw materials. And even better: they simply dissolve in the hot water and can be eaten as an additional protein boost.

Roboticists at the Max Planck Institute for Intelligent Systems in Stuttgart have developed a jellyfish-inspired underwater robot with which they hope one day to collect waste from the bottom of the ocean. The almost noise-free prototype can trap objects underneath its body without physical contact, thereby enabling safe interactions in delicate environments such as coral reefs. Jellyfish-Bot could become a tool for environmental remediation.

"Programmable" polymer materials - 24/04/2023

Medicine of the future: intelligent 4D polymers from the printer

It is impossible to imagine medicine without 3D printing, which can be used to make implants or for culturing cells and tissues. It is now possible for 3D objects to be given an added dimension, namely an ability to make simple autonomous movements, by changing their size. Researchers at Heidelberg University have been able to produce microscopically small 4D structures from intelligent polymers that can be tailored to individual requirements.

Konstanz researchers discover the function of a previously unexplored protein: In three characteristic steps, "C12orf29" links the ends of RNA strands. Proteins that perform this kind of RNA ligation were previously unknown in humans. The results of the study suggest that it is important for RNA repair during cellular stress.

In collaboration with the project partners CG TEC, Cordenka, ElringKlinger, Fiber Engineering and Technikum Laubholz, the DITF are developing a new fiber composite material (CELLUN) with reinforcing fibers made of cellulose. The matrix of the material is a thermoplastic cellulose derivative. CELLUN made from renewable biopolymers enables the replacement of glass or carbon fibers in the production of industrial molded parts.

Heidelberg University is to acquire a research building to develop innovative engineering science strategies and technologies on the basis of life-inspired molecular systems. The German Science and Humanities Council has now expressed its backing for the idea with an outstanding rating. This recommendation is the crucial precondition for a new building on the university campus Im Neuenheimer Feld.

The Phytopharmaceuticals and Valuable Plant Ingredients initiative aims to further develop phytopharmaceuticals and valuable plant ingredients in Baden-Württemberg.

Tablet-based diagnostics - 12/04/2023

TuCAN - innovative diagnostic procedure for neuropsychiatric disorders

Neuropsychiatric disorders are often diagnosed late and have a negative impact on quality of life. Diagnosing the disease at an early stage is vital to be able to help those affected by offering them treatment adapted to their specific requirements. This is what the TuCAN project in Tübingen aims to achieve through the early and differential diagnosis of neuropsychiatric disorders.