Article - 14/09/2022

Theranostics of prostate cancer: the combination of radionuclide diagnostics and radionuclide therapy

Using a low-level radiopharmaceutical that binds to the prostate-specific membrane antigen (PSMA), positron emission tomography/computed tomography can be used to visualise even small prostate cancer metastases. Developed by Heidelberg researchers, the radiopharmaceutical is a modified radionuclide diagnostic agent that has been coupled with a powerful emitter and used as a therapeutic tracer to irradiate and destroy cancer cells from within.

In its statement of September 2, 2022, the Bioeconomy Council of the German government condemns the Russian war of aggression on Ukraine and points out ways in which the resulting food and energy crisis can be alleviated with the help of the bioeconomy.

Cancer cells often grow in environments that are low in nutrients, and they cope with this challenge by switching their metabolism to using proteins as alternative "food". Building on genetic screens, an international team of scientists could identify the protein LYSET as part of a pathway that allows cancer cells to make this switch. Their findings are now published in the journal Science.

Dossier - 08/09/2022

Imaging methods in medical diagnostics

Many different imaging methods are available these days and are used in almost all medical disciplines to visualise disease-related changes. Depending on the problem and the clinical picture, very different structural and functional parameters can be visually recorded for diagnosis and used for therapy.

Today, genome editing is almost as easy as programming software. However, the generation of viral vectors as initial material is still associated with many expensive and error-prone handling procedures. Viruses are generated via complex biological processes that have to be optimised virus-specifically in order to produce high-quality therapeutics. A new method is needed that simplifies and optimises these processes.

Sustainable nutrition - 05/09/2022

Insect pasta: eating healthily and improving the world at the same time

Insects on the dinner plate? Some people instantly dismiss the idea. Wrongly so, because in terms of animal welfare, ecological footprint and healthy nutrition, insect foods are much better than all other animal foods and are produced in a more controlled way. The fact that they can also taste really good is proven by the start-up Beneto Foods from Albstadt, which has developed protein-rich pasta in various flavours using cricket flour.

Tuberculosis is one of the leading causes of death worldwide, with an estimated 1.4 million deaths and ten million people infected annually. Resistant and multidrug-resistant (MDR) variants of the tuberculosis pathogen Mycobacterium tuberculosis pose a major threat to tuberculosis control and global health.

Changes known as epigenetic modifications play an important role in cancer development, among other things. Being able to analyze them quickly and reliably could, for example, contribute significantly to the further development of personalized therapy.

Project BW2Pro - 29/08/2022

Biowaste to Products: biorefinery transforms biowaste into new products

In 2020, Germany’s population collected over 5 million tonnes of biowaste. Most of this was composted, and some was fermented into biogas. Scientists in Baden-Württemberg think there's room for more. Within the project ‘Biowaste to Products’ (BW2Pro) they want to transform biowaste into new products in a biorefinery. The idea is to produce biodegradable plant pots, mulch material, fertilisers, enzymes and biobased plastics in addition to…

CureVac N.V., a global biopharmaceutical company developing a new class of transformative medicines based on mRNA, today announced the start of a Phase 1 study of the modified COVID-19 mRNA vaccine candidate CV0501, administered as a booster dose to previous COVID-19 vaccination. Developed in collaboration with GSK, CV0501 is based on CureVac’s second-generation mRNA backbone and is designed to specifically protect against the Omicron variant.

University of Tübingen team discovers how malformations of the blood vessels can occur in mice – yielding information with possible ramifications for retinal disease.

In mice, inflammation in early to mid-life leads to a permanent decline in functional blood stem cells, according to a recent publication by scientists from the German Cancer Research Center (DKFZ) and the Stem Cell Institute HI-STEM*. The ability of the blood stem cells to regenerate was suppressed for at least one year after challenge with inflammation.

A centre for model-based artificial intelligence has been set up at Heidelberg University to link mathematical modelling methods with information processing in neuronal networks. The Carl Zeiss Foundation (CZS) is funding the CZS Heidelberg Center for Model-Based AI with five million euros over a period of six years.

RHEACELL GmbH - 28/07/2022

Innovative stem cell therapy for chronic wounds

Non-healing, chronically inflamed wounds can be very painful and carry the risk of serious infections. The Heidelberg company RHEACELL has developed a unique drug based on ABCB5-positive mesenchymal stem cells that helps reprogramme the relevant immune cells and promote healing.

Carbon sequestration - 28/07/2022

Carbon farming - climate protection on agricultural land?

Agriculture plays a key role in helping to achieve European climate targets. Central to this goal are measures that are collectively referred to as carbon farming and are often used for offsetting greenhouse gas emissions. Two Baden-Württemberg companies - CarboCert and Carbonfuture - are active in addressing the challenges and potentials of carbon farming.

In Provence, the lavender fields are in full bloom again. This blaze of color may soon also be seen in Baden-Württemberg. In a joint research project, the German Institutes of Textile and Fiber Research Denkendorf (DITF), the University of Hohenheim and the company naturamus are testing suitable lavender varieties and developing energy-efficient methods for producing essential oil from them.

Organ-on-chip for the analysis of drug effects - 20/07/2022

New 3D cell platform allows continuous metabolic monitoring

Organ-on-chips systems are systems containing miniature tissues grown inside mircrofluidic chips. By integrating microsensors, researchers at the IMTEK Freiburg, together with the RWTH Aachen University Hospital, created a novel variant that allows the measurement of metabolic activity directly on site and in real time. This enables the rapid and detailed analysis of drug effects outside an organism.

AaviGen GmbH: Hope for heart failure - 14/07/2022

Gene therapy for weakened hearts

Treating a weak heart – for example after a heart attack – at the GP’s surgery with a single intravenous injection, without causing serious side effects: what sounds almost too good to be true is actually already under development. The Heidelberg-based biotech company AaviGen is working on a platform technology based on adeno-associated viruses that can help introduce therapeutic genes in a highly specific way into diseased heart muscle cells.

Biotech in outer space - 06/07/2022

yuri, a space start-up: weightlessness for commercial research

Growing cells without the effect of gravity could revolutionise drug development. A start-up called yuri on Lake Constance enables made-to-measure experiments on the ISS for stem cells, artificial organs, surfaces and materials. On board the next mission are some mini-cell labs from Berlin's Charité and Goethe University Frankfurt.

Hearing loss - 29/06/2022

Innovative micro loudspeaker brings back hearing

Hearing loss often severely restricts the lives of those affected and can only be partially reversed with conventional hearing aids. The innovative hearing aid developed by Vibrosonic GmbH from Mannheim transmits sound vibrations directly to the eardrum and can thus almost completely restore the natural hearing experience.

Mitochondria are the power plants of cells, and they contain their own genetic material and RNA molecules. Scientists from the German Cancer Research Center (DKFZ) have now discovered that certain modifications in mitochondrial RNA boost the invasive spread of cancer cells by supporting protein synthesis in mitochondria.

Paludiculture as a beacon of hope for the climate - 28/06/2022

Peatlands as CO2 reservoirs: simultaneous renaturation and use

Peatlands store more carbon dioxide than any other ecosystem in the world. However, when drained, they become a climate-damaging source of CO2. The management of wet peatlands reveals exciting solutions, with market potential in the areas of local heating, insulation, packaging and even peat substitution.

Does COVID-19 vaccination increase the risk of cancer patients undergoing therapy with immune checkpoint inhibitors to suffer a dangerous immune complication known as a "cytokine release syndrome"? A team of Heidelberg physicians and scientists has now shown in a clinical study: Increased serum levels of the characteristic cytokines occur frequently in cancer patients, but clinically relevant cases of the dreaded syndrome were not…

Press release - 22/06/2022

Concluding conference of the ARDIA-Net Interreg project

On May 11, the concluding conference of the ARDIA-Net Interreg project took place with 18 in-person attendees in Milan and 18 online participants. The programme for the half-day event included presentations and two panels on the project results as well as discussions on further cross-regional cooperation.