Dossier - 16/12/2021

Advanced therapy medicinal products: gene and cell therapies

Novel gene and cell therapies for treating incurable and hereditary diseases have raised high expectations. However, success has so far been limited to the long-established bone marrow transplants involving the administration of haematopoietic stem cells used to treat blood cancer. CAR T-cell therapies have recently emerged as a major new hope in cancer treatment.

For the second time, the nova Institute for Ecology and Innovation is honouring outstanding scientific research that provides sustainable solutions for the cellulose fibre value chain as part of the "International Conference on Cellulose Fibres 2022". The DITF Denkendorf is one of the six nominees.

Plant residues - 14/12/2021

Straw pulp: agricultural residues become sanitary paper products

Straw cannot yet be spun into gold, but in Mannheim, Germany, it is being turned into something else of great value: Essity is the first and only company in Europe to produce toilet paper and kitchen rolls from wheat straw in a new pulp mill. From next year, these sustainable sanitary paper products will be found on supermarket shelves.

Today, the EU Parliament adopted the EU Regulation on Health Technology Assessment (HTA), which includes not only new medicines (including gene and cell therapies), but also medical devices.

A new interdisciplinary research project aims to uncover information that can help decode hereditary colon cancer with the aid of mathematical models. Mathematicians and tumour biologists of Heidelberg University, the Heidelberg Institute for Theoretical Studies, Heidelberg University Hospital, and the German Cancer Research Center are collaborating on the project.

Renewable raw materials and the circular economy in the textile industry - 08/12/2021

Outdoor equipment made from cellulose, castor oil and coffee grounds - functional and durable

VAUDE develops outdoor gear made from natural or recycled materials that are harmless to people and the environment while protecting against the wind and rain. The company relies on renewable raw materials, biobased plastics and the circular economy.

The development of immunotherapies against blood cancer could be more successful if T cells are activated moderately rather than excessively. Scientists from the German Cancer Research Center have now been able to show this in mice: If the researchers blocked a cytokine that slows down the immune system, the T cells became exhausted and failed in the fight against leukemia.

At Tübingen University Hospital, a preclinical study led by Dr. Clemens Hinterleitner and Prof. Dr. Lars Zender, Medical Director of Medical Oncology and Pneumology, led to extremely promising results. The research group was able to develop a new methodology that makes it possible to better predict the likelihood of success of immunotherapies for lung cancer.

Press release - 03/12/2021

ARDIA-Net preliminary results presented in the Kick-Off Conference of Interreg Alpine Space 2021-27

The Kick-Off Conference of the new Interreg Alpine Space programme, which gathered more than 300 attendees, was organized by the Joint Secretariat in Salzburg and held online due to the COVID-19 restrictions established by the Austrian Government days previous to the celebration. It consisted of a two half-day programme (22nd and 23rd of November) under the motto “Let’s change our altitude”.

Gene regulation as a starting point for cancer therapies - 02/12/2021

New investigation method for deciphering complex epigenetic networks

The development and maintenance of uncontrolled cell division in tumours is often due to the unbalanced, complex interplay of regulatory epigenetic networks. Researchers at the Institute of Biochemistry and Technical Biochemistry in Stuttgart have developed a new screening system to identify essential components that can serve as targets for anticancer drugs.

Parkinson's disease is characterised by a slow, progressive loss of nerve cells in certain brain areas. The disease is still incurable and the exact causes are unclear. The dopamine deficiency in the brain can only be controlled to some extent in the initial phase of the disease. Basic research is being conducted in an attempt to unravel the mystery of Parkinson's disease.

In multiple myeloma, a cancer of the bone marrow, relapse almost always occurs after treatment. Initially, most patients respond well to therapy. However, as the disease progresses, resistant cancer cells spread in the bone marrow, with fatal consequences for the patients.

Laboratory automation - 29/11/2021

Reaching the goal quickly and efficiently with the help of artificial intelligence

Medical research is slow, costly and time-consuming. The system developed by the start-up LABMaiTE could soon change that. With the help of artificial intelligence, it will be possible to automate laboratory experiments and collect and analyse data at the same time.

Further utilisation of plant residues - 25/11/2021

Novel fibre composite made from hop fermentation residues

Biogas plants produce energy-rich gas by fermenting biomass. This process generates both liquid and solid fibrous and particulate fermentation residues. Researchers at the German Institutes of Textile and Fibre Research (DITF) have now managed to create a resistant and water-repellent fibre composite material from solid hop residues that can be used as a veneer to coat wood panels.

Cluster of the future - 25/11/2021

nanodiagBW: using nanopores to create completely new diagnostic possibilities

Modern medicine has a wide range of molecular diagnostics at hand. In the next decade, this will increasingly be supplemented by prognostic methods. The BMBF Cluster of the Future finalist, nanodiag BW, is developing prognostic methods to identify epigenetic factors for diseases through a new type of bioanalytics – single molecule analysis in nanopores – which would make it possible to take personalised prevention approaches.

In reforestation projects, the seedlings must be protected. So-called growth covers prevent game from feeding on the young plants and help to ensure that they are not prevented from growing by other plants. Previously used sheaths made of plastic and metal are often not removed in time and pollute the environment. The DITF have developed a biodegradable yarn for growth covers from renewable raw materials.

After a highly competitive process Ulm University has been awarded its fifth Collaborative Research Centre (CRC). The new CRC 1506 ‘Aging at Interfaces’ addresses one of the most urgent medical challenges of our time: the aging of the human body and the diseases and constraints that are frequently associated with the aging process.

At the University Hospital Tübingen, clinical evaluation of an in-house developed vaccine (CoVac-1) against SARS-CoV-2 was started in November 2020 under the direction of Prof. Dr. Juliane Walz in the CCU Translational Immunology of the Medical Clinic (Medical Director Prof. Dr. Helmut Salih). Now the results of the Phase I study are available and demonstrate a potent activation of the T-cell response against the coronavirus.

The Cluster of Excellence IntCDC of the University of Stuttgart presents the "Maison Fibre" at the International Architecture Exhibition Venice. The full-scale inhabitable installation is made from robotically produced, fibrous building elements.

Furtwangen University publishes the world’s first molecular biological study on bacterial contamination of slit lamps. Slit lamps are among the most important tools used by ophthalmologists and opticians. They allow selected areas of the eye to be magnified and examined for diseases.

As cancer progresses, the tumor cells continually change, ultimately resulting in a tumor consisting of a large number of different cell clones with different characteristics. This is referred to as "tumor heterogeneity". In many cases, the cancer cells become resistant to the treatments available.

Treatment resistance is a central problem in the treatment of cancer. Bone and soft tissue tumors – known as sarcomas – in adolescents and young adults often stop responding to treatment too. This is because cancer cells develop a large number of new characteristics as the disease progresses and often become resistant to drugs that were originally effective.