CureVac N.V., a global biopharmaceutical company developing a new class of transformative medicines based on messenger ribonucleic acid (“mRNA”), today announced the strategic decision to focus its COVID-19 vaccine development towards the development of second-generation mRNA vaccine candidates in collaboration with GSK and to withdraw its first-generation COVID-19 vaccine candidate, CVnCoV, from the current approval process.

Optimised peptides against infections and cancer - 07/10/2021

New bioactive ingredients from the peptidome treasure chest

Peptides are increasingly coming into scientific focus for application in diagnostics and therapy. The human body is full of these protein fragments, but only a fraction have been characterised. So there is enormous potential for discovering new biologically active substances that can help in the fight against bacteria, viruses and cancer. A collaborative research centre at Ulm University Hospital is on the trail of these promising fragments.

International research collaboration explores the properties of different neuron types in the brain motor cortex of mice, monkeys and humans using novel experimental and data analysis techniques.

The bio-based industries continue their ascent marking a total contribution of 780 billion EUR, a notable increase of 30 billion EUR (+ 4%) compared to 2017. This represents a more than 20% increase compared to 2008 which is the earliest data taken into account in this series of reports by nova-Institute. The first report of the series was first commissioned by the Bio-based Industries Consortium (BIC) in 2017.

A pioneering technique developed by the Prevedel Group at EMBL allows neuroscientists to observe live neurons deep inside the brain – or any other cell hidden within an opaque tissue. The technique is based on two state-of-the-art microscopy methods, three-photon microscopy and adaptive optics. The paper reporting on this advancement was published on 30th September 2021 in Nature Methods.

Hygiene and health company Essity is today presenting a breakthrough in sustainable tissue production and is beginning production based on pulp from wheat straw. The plant in Mannheim, Germany, is the first of its kind in Europe, and the first on a large-scale tissue production in the world.

The research project RUN (Rural Urban Nutrient Partnership) explores how waste might be used more efficiently as a resource. In this project, Veronika Fendel investigates how recyclable materials from biowaste and domestic wastewater can be fed back into the material cycle in the best possible way.

Microorganisms can increase their host’s ability to adapt to the environment and reproduce – evolutionary biologists are now studying the underlying molecular mechanisms. A research team headed by Dr. Fabian Staubach and Yun Wang from the Institute of Biology I at the University of Freiburg has now studied the relationship of Gluconobacter bacteria and fruit flies. They have found that specific Gluconobacter variants supply the flies with vitamin…

Start-up PROSERVATION - sustainable packaging - 21/09/2021

Husk as a substitute for polystyrene: packaging materials with a good conscience

Expanded polystyrene (EPS) packaging is very practical, but it is made from petroleum and is not very environmentally friendly in other ways either. Single-use plastic containers made of EPS have therefore been banned in the EU, but alternatives are also urgently needed. The Stuttgart-based start-up PROSERVATION has developed an ecological packaging material made from grain husks that could replace EPS and be just as effective.

A team of engineers and biotechnologists at the University of Freiburg has for the first time shown in mammals that the concentration of antibiotics in the body can be determined using breath samples. The breath measurements also corresponded to the antibiotic concentrations in the blood. The team’s biosensor – a multiplex chip – will in future enable personalized dosing of medicines against infectious diseases on-site.

Cyber Valley researchers have created medical educational tools that could potentially train the surgeons of the future, much like flight simulators train pilots. The team developed a range of artificial organ phantoms to serve as training platforms for surgeons. Thanks to the structured data of experienced medical professionals, a quantitative and objective assessment of a trainee’s skills can be assessed in real time.

Personalised medicine - 16/09/2021

Pharmacogenomics enables individualised drug prescription

Every person is unique, and their reaction to medications can be just as individual. For this reason, unexpected side effects occur time and again with common drugs, sometimes with life-threatening consequences. At the Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology (IKP) in Stuttgart, the influence of hereditary factors on these harmful reactions is being investigated in order to enable individualised therapies.

Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have developed antibodies that have two antigen-binding sites and can couple cancer cells with effector cells of the immune system. In laboratory tests, these bridging antibodies, together with an enhancer antibody, were able to specifically mobilize the body's own immune defenses and destroy breast cancer cells.

Scientists use super-resolution microscopy to study previously undiscovered cellular worlds, revealing nanometer-scale details inside cells. This method revolutionized light microscopy and earned its inventors the 2014 Nobel Prize in Chemistry. In an international collaboration, AI researchers from Tübingen have now developed an algorithm that significantly accelerates this technology.

Christiane Opitz, scientist at the German Cancer Research Center, is being awarded this year's Ita Askonas Prize of the European Federation of Immunological Societies. Opitz has discovered how tumor cells use certain metabolites to protect themselves against the immune system. Her research findings may provide important clues for the development of new therapeutic concepts.

On the one hand, blood vessels supply tumors with nutrients and, on the other, enable cancer cells to spread throughout the body. The settlement of circulating tumor cells in a distant organ is promoted by factors whose production is induced by the primary tumor itself. Scientists have now identified a new growth factor produced by blood vessels that enables tumor cells to metastatically colonize organs.

As a rapidly growing renewable raw material, bamboo is an ideal substitute for wood. However, bamboo’s susceptibility to mold in damp conditions poses a problem. Researchers at Fraunhofer have now analyzed bamboo’s response to moisture under specific climatic conditions. By using simulation software, building owners can plan and implement measures to prevent the growth of mold.

Reduction of greenhouse gases in wine production - 31/08/2021

The REDWine project and climate change

In the EU project REDWine, the CO2 produced during wine fermentation is captured and used to produce algae biomass. Novis GmbH from Tübingen supplies the complete system for CO2 utilisation. The aim of the project is to reduce the share of global warming caused by wine production in a way that is economical for producers.

Expert interview - 31/08/2021

Health Data Scenarios - many possibilities for the future?

The digitization of healthcare is progressing slowly but steadily. In addition to simple telemedical applications, data such as electronic patient records are forming the basis of digitization. The ‘Health Data Scenarios’ project aims to model the future of healthcare data by using scenarios. Lucas Scherdel, Healthcare Innovation Director at DayOne, and Dr. Alexander Fink, founder and CEO of ScMI AG, explain how this will work.

CureVac N.V. (Nasdaq: CVAC), a global biopharmaceutical company developing a new class of transformative medicines based on messenger ribonucleic acid (“mRNA”), today announced the publication entitled “Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model” in the peer-reviewed Journal of Hepatology.

In August 2021, the BioMat Pavilion 2021 was inaugurated on the campus of the University of Stuttgart in a ceremonial setting and in compliance with the hygiene concept. The core of the elegantly curved lightweight construction is an active-bending structure made of natural fibers, reminiscent of bamboo. It was developed as part of the "LeichtPRO" research project.

An international research team has calculated the potential for material efficiency strategies in residential buildings and passenger cars. Up to two-thirds of global emissions could be saved in these areas, provided that appropriate strategies are consistently implemented.

New drugs are intended to help stop viral zoonoses – infections that jump from animals to humans. To study suitable inhibitors, Prof. Dr Christian Klein from the Institute of Pharmacy and Molecular Biotechnology (IPMB) of Heidelberg University is receiving funding in the amount of 450,000 euros from the Volkswagen Foundation.

3R-Center - 18/08/2021

Putting alternatives to animal testing into practice

Animal experiments are still central to biomedical research. However, it has become increasingly clear that not all of them are absolutely necessary. Alternative techniques exist. The new 3R-Netzwerk Baden-Württemberg is now seeking to promote these more vigorously - and improve animal welfare in cases where alternatives to animal testing are not available.

The risk of colorectal cancer can be predicted more accurately by determining seven blood-based micro-RNAs (miRNAs) than by using traditional methods - and can be done so many years before a diagnosis is made. In a current study, researchers from the German Cancer Research Center and the National Center for Tumor Diseases (NCT) Heidelberg show that miRNA profiles provide greater predictive accuracy than genetic or lifestyle-based risk…