Computer-assisted genome mining - 04/12/2023

Natural product genomics opens up new avenues in the search for antibiotics

Antibiotic-resistant pathogens are increasingly endangering our health. Since most of the drugs currently in use are based on secondary metabolites produced by bacteria or fungi, the research group of Prof. Dr. Nadine Ziemert in Tübingen is developing bioinformatic tools to specifically search the genome of these organisms for previously unknown antimicrobial agents.

University of Tübingen researchers reverse the evolution of a class of antibiotics to gain insights for the development of new drugs.

Heidelberg scientists unveil genetic programmes controlling the development of cellular diversity in the cerebellum of humans and other mammals. The research results have now been published in the journal Nature.

The progression of multiple sclerosis (MS) can usually be slowed down with medication, but a cure is currently not possible. It is now established that Epstein-Barr viruses are involved in the development of MS. However, it is not known how the pathogens trigger the disease. The European Union is now funding the international research consortium BEHIND-MS as part of its HORIZON Europe program.

Recent research shows effectiveness of biosurfactants - 28/11/2023

Combating oil spills - biosurfactants can stimulate microbial oil degradation

Oil spills from drilling platforms and tankers cause environmental pollution and a loss of biodiversity. Researchers at the University of Stuttgart, among others, are now using biosurfactants to improve the management of oil spills: their latest research shows that biosurfactants lead to better microbiological degradation of oil components in seawater compared to conventional dispersants.

The AlbLavendel project - 20/11/2023

Swabian lavender cultivation: aesthetic and sustainable

Blue-violet, fragrant fields like those in Provence may soon become a common sight in the Swabian Alb. As part of the AlbLavendel project, the University of Hohenheim along with the company naturamus GmbH and the German Institutes of Textile and Fibre Research Denkendorf has started to investigate the cultivation of lavender, the production of essential oils and the use of distillation residues for producing textile fibres in the local region.

Pancreatic cancer is one of the deadliest types of cancers in humans. Chemotherapies attack not only the tumor cells but also healthy cells throughout the body. Innovative nanoparticles could be a new approach to treat cancer more precisely. The approach was developed by a research team from the Max Planck Institute (MPI) for Multidisciplinary Sciences, the University Medical Center Göttingen (UMG), and the Karlsruhe Institute of Technology.

Augmented reality for visual orientation - 15/11/2023

Fall prevention with the help of balance-enhancing AR glasses

As we age, our eyesight deteriorates and we have increasing difficulties with orientation. This can lead to balance problems and fatal falls. A team led by Dr. Lorenz Assländer from the University of Konstanz is currently developing a prototype of augmented reality (AR) glasses that use superimposed patterns to facilitate visual orientation in space, thereby helping to improve balance control and prevent falls.

All cancer cells - even those within the same tumor - differ from each other and change over the course of a cancer disease. Scientists at Heidelberg University Hospital, the Medical Faculty in Heidelberg and the German Cancer Research Center discovered molecular changes in multiple myeloma that help individual cancer cells to survive therapy.

Nanoparticles as drug carriers - 09/11/2023

Inhalation of nanocarriers for antibiotics against resistant tuberculosis pathogens

Around ten million people worldwide still contract tuberculosis every year. With an estimated 1.4 million deaths a year, tuberculosis was the world’s deadliest infectious disease until COVID-19. The high mortality rate is down to the sophisticated biology of the pathogen Mycobacterium tuberculosis. A team of researchers from the KIT and the Research Centre Borstel (FZB) has developed a method that aims to outsmart the bacterium once and for all.

Climate-neutral wastewater treatment plants thanks to patented real-time analytics - 08/11/2023

Using AI to reduce greenhouse gases in wastewater companies

The wastewater industry is responsible for global greenhouse gas emissions equivalent to those of global aviation. The start-up Variolytics has found a way to significantly reduce greenhouse gases in wastewater treatment plants using real-time analytics. The patented sensor technology and AI-supported process optimisation offer multiple benefits: in addition to reducing nitrous oxide, the system helps to reduce energy costs and resources.

CAR-T cell therapy is a last hope for many patients with blood, bone marrow or lymph gland cancer when other treatments are unsuccessful. A limiting factor of this very effective and safe therapy is that the cells used in the process quickly reach a state of exhaustion. Researchers at the University of Freiburg have now been able to prevent this exhaustion and thus significantly improve the effect of the therapy in a preclinical animal model.

The Sustainability Innovation Campus (ICN) initiated by the University of Freiburg and the Karlsruhe Institute of Technology (KIT), which will begin its work in January 2024, has announced a two-year funding programme for start-up projects. Scientists from the University of Freiburg, KIT and cooperating universities and research institutions are invited to submit their project outlines by 30 November 2023.

Wasser 3.0: #detect|remove|reuse - 31/10/2023

How to sustainably remove and recycle microplastics from water

We all pollute our water with things we use in our everyday lives. In the process, microplastics and micropollutants accumulate in sometimes significant quantities and are difficult to remove. This has increasingly devastating consequences for our health and the environment. Wasser 3.0, a non-profit start-up from Karlsruhe, has declared war on this problem by developing a customisable process to detect, remove and even recycle these pollutants.

An interdisciplinary research group combining mechanical engineering and biotechnology has taken up its work at the Institute for Molecular Systems Engineering and Advanced Materials (IMSEAM) of Heidelberg University. The team under the direction of Dr Kai Melde will pursue an innovative approach to biofabrication – 3D cell culture using ultrasound. Tools are being developed that can be used as an alternative to or enhancement for 3D printing.

Textiles are a given in civil engineering. Until now, textiles made of resistant synthetic fibers have been used for this purpose, having a long lifetime. For some applications, however, it would not only be sufficient but even desirable for the auxiliary textile to degrade when it has done its job. Natural fibers, in contrast, often decompose too quickly. The DITF are developing a bio-based protective coating that extends their service life.

High-resolution microscopy technology bypassing the diffraction limit - 26/10/2023

From micro- to nanoscope

It has long been impossible to distinguish objects closer than 200 nanometres using light microscopes. However, novel devices developed by a company called abberior Instruments GmbH, which use technology developed by Nobel Prize winner Prof. Dr. Stefan Hell and his teams in Heidelberg and Göttingen, are now able to bypass this resolution limit and provide detailed insights into living cells in the lower nanometre range.

Jun.-Prof. Dr. Priscilla Briquez, junior professor at the Department of General and Visceral Surgery at the Freiburg University Medical Center and member of the Medical Faculty at the University of Freiburg, has received a European Research Council (ERC) Starting Grant from the European Commission. Her DRESSCODE project will receive a total of 1.5 million euros funding for five years.

Epigenetically active drugs enable the cell to read parts of the genome that were previously blocked and inaccessible. This leads to the formation of new mRNA transcripts and also new proteins, as scientists from the German Cancer Research Center and the University Hospital Tübingen have now published. These "therapy-induced epitopes" could help the immune system recognize cancer cells.

Epigenetically active drugs enable the cell to read parts of the genome that were previously blocked and inaccessible. This leads to the formation of new mRNA transcripts and also new proteins, as scientists from the German Cancer Research Center and the University Hospital Tübingen have now published. These "therapy-induced epitopes" could help the immune system recognize cancer cells.

A researcher team from Ecole Polytechnique Federal de Lausanne led by Dr. Vivek Thacker now group leader at the Department of Infectious Diseases at Heidelberg University Hospital have studied why tuberculosis bacteria form long strands and how this affects their infectivity. Their findings could lead to new therapies and have now been published in the journal Cell.

Why are severe courses of SARS-CoV-2 infection less common in children and adolescents than in adults? Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now discovered that the immune system in the upper respiratory tract is much more alert and active in children before infection than in adults and is therefore better equipped to fight the virus.